共刺激分子B7在T淋巴细胞的激活过程中发挥了重要作用,是目前人们最感兴趣的共刺激分子之一.属lg超家族,主要表达活化的B淋巴细胞,其对应受体是CD28分子及CTLA-4.T细胞对肿瘤的反应需要肿瘤抗原多肽由MHCI类分子提呈给CD8~+T细胞或由MHCⅡ类分子提呈给CD~+T细胞.B7分子可协同诱导有效的,且为MHC限制的和肿瘤特异的抗肿瘤免疫,这可为肿瘤的基因治疗提供新的途径和思路.

To exert the hematopoietic and immunoregulatory effects of IL-3 more effectively, the murine model of fibroblast-mediated IL-3 gene therapy was established, and the changes of peripheral blood cells and splenocytes were observed. By gene transfection, G41

R285.5 R446

本文受国家自然科学基金优秀中青年人才专项基金(39421009)资助