通过不同途径(局部/介入法,静脉滴注法)注射肿瘤浸润淋巴细胞,比较其有效率、一年生存率。发现局部/介入法的有效率(85.7％)高于静脉滴注法(48.6％),而前者的一年生存率低于后者,局部/介入、静脉滴注一年生存率分别为66％、80％。分析其原因,发现静脉滴注后肿瘤患者外周血中的CD3~ ,CD4~ 、CD8~ 均明显提高,增多率高于局部注射法,但静脉滴注法和静脉 局部的增多率相似(P>0.05)。提示:静脉滴注能提高肿瘤患者的全身细胞免疫功能而使一年生存率提高。

Sixty - eight cancer patients were treated with tumor infiltrating lymphocytes transferred by local injection (local group) , in vein injecition (vein group) and in vein local injection (vein local group) respectively. We have analysed the anticancer efficacy and one year survival rate of patients with different transfer ways. It showed that the anticancer efficacy of the local group (85. 7%) was higher than that of vein group (48. 6%), but the one year survival rate of local group (66%) was lower than that of the vein group (80%). Comparative studies on circulating lymphocytes of cancer patients demonstrated that the increase of CD3 , CD8 , CD4 T lymphocytes of vein group were higer than that of local group, but not different from that of vein local group. These results suggest the possibility that in vein transfer of TILs could induce immuno -activation of cellular immunity to enhance the one year survial rate.