[关键词]
[摘要]
Metastasizing cancer cells can invade the extracellular matrix using surface motor organelles,termed invadopodia that contact and dissolvethe matrix.Various membrane-bound proteases and their associated proteins such as integrins localized on the invadopodial membranes are re-sponsible for the extracellular matrix degradation and cell invasion,A control mechanism of cancer invasion and metastasis may involve the for-mation of such invadopodial protease assembly(IPA),induction of IPA,and the regulation of invasion by a novel immune complex in senum.
[Key word]
[Abstract]
Metastasizing cancer cells can invade the extracellular matrix using surface motor organelles,termed invadopodia that contact and dissolvethe matrix.Various membrane-bound proteases and their associated proteins such as integrins localized on the invadopodial membranes are re-sponsible for the extracellular matrix degradation and cell invasion,A control mechanism of cancer invasion and metastasis may involve the for-mation of such invadopodial protease assembly(IPA),induction of IPA,and the regulation of invasion by a novel immune complex in senum.
[中图分类号]
R73-37
[基金项目]
