目的:探讨非靶器官肿瘤(原发性支气管肺癌)是否存在雌激素(estrogen receptor ER)、孕激素受体(progesterone recep-tor.PR)及ER、PR与肿瘤的关系,方法:146例手术切除原发性支气管肺癌标本,按WHO肺癌组织学分类标准进行光镜诊断;运用免疫组织化学ABC法进行石蜡切片的ER,PR检测 结果:ER阳性检出率58.9%,PR阳性检出率69.1,双阳46.6%.提示雌孕激素受体阳性率与肿瘤分化程度呈正相关、与组织学类型、肿块大小、患者年龄、性别无关 结论:非小细胞肺癌组织中存在性激素受体,将其作为激素辅助治疗的一个指标,有一定的应用前景

Objective: To investigate estrogen receptor (ER) and progesterone receptor (PR) in the tumor derived from non-target organ (primary bronchogenic carcinoma), and correlation with the tumor. Methods: According to WHO histo-logical classification of lung tumors, 146 resected specimens of lung canrer were examined microscopically; ER and PR were detected on paraffin-embedded tissue sections using immunohistochemical staining. Results: 58.9% of the cases were positive for ER, 69. 1 % for PR,and 46.6% positive for both. There was a significant correlation between ER and PR positive percentage and degrees of histological differentiation in lung cancer, while ER and PR percentage appears to have no relationship with histological type, tumor size, age and sex of the patients. Conclusion: It is demonstrated that ER and PR are present in non-small cell lung cancer. These observation may provide a basis for adjuvant hormonal therapy in selected lung cancer patients.