研究放射免疫治疗（RIT）对肿瘤转移的预防和治疗作用,寻找一种抑制肿瘤转移的方法。方法： 采用131I C50治疗LA795肺腺癌小鼠模型。通过观察治疗前后小鼠的体重减轻量、瘤重、生存期、肺转移数。比较一、小鼠接种后不同时间给药分次小剂量RIT与化疗、手术及对照组之间疗效差别。二、接种后不同时间截肢后综合治疗对荷瘤小鼠作用。结果： 一、接种后第7天给药，各治疗组与对照组比较，体重减轻少、瘤重轻、肺转移结节数少，以分次小剂量RIT组最优。接种后第4天给药，与对照组比较疗效进一步提高。二、接种后第15天手术，分次小剂量RIT组、化疗组比单次大剂量RIT组及对照组小鼠生存期延长，肺转移结节数减少，分次小剂量RIT优于化疗。接种后第8天手术，与对照组比较疗效进一步提高，且分次小剂量RIT组最优。结论： 分次小剂量RIT优于单纯化疗、手术；提前给药分次小剂量RIT疗效更优；分次小剂量RIT结合手术的综合治疗能明显放大小剂量RIT的抑瘤效应；尽早实行综合治疗疗效更优。

To study the efficiency of radio-immuno-therapy (RIT) with 131 I-C50 to precaution and treatment of tumor metastasis and develop a new metastasis suppression method. Methods: The effect was judged through body weight loss, tumor burden, life-span, and metastatic. Compared among the multiple low-dose RIT, chemotherapy, surgical resection and controls in different administration time after implantation of tumor and resection of tumor. Results: When the treatment was initiated at 7th day after implantation, the tumor suppression effects of treatment groups were significantly better than those of controls, with the best one in multiple low-dose RIT. Better results were achieved by starting treatment earlier. Surgical resection at 15th day after implantation, multiple low-dose RIT groups gained longer life-span and less metastatic nodules than others. Early operation improved therapeutic efficacy, especially in multiple low-dose RIT. Conclusion: Multiple low-dose RIT alone is better than chemotherapy and surgical treating. Early doing RIT is better than latter. One low-dose RIT plus with operation had even better tumor suppression effect than RIT alone. Low-dose RIT co-operated with operation as early as possible can enhance the effects of treatment.

R730.51 R392.1

* 该项研究得到军队九五课题资助(96M135)