目的：观察因接受同步放化疗而出现白细胞低下并同时伴有口腔黏膜炎的局部晚期头颈部肿瘤患者，在接受G（M）-CSF治疗以提升白细胞的同时，G（M）-CSF对口腔黏膜炎的治疗作用。方法： 15例局部晚期头颈部肿瘤病人在接受同步放化疗中，当白细胞≤1.5×10 9/L并同时伴有Ⅲ~Ⅳ度口腔黏膜炎时，给予G-CSF（惠尔血）150~300 μg/日或G（M）-CSF（生白能）200~300 μg/日，皮下注射，连用5～10 d。结果： 所有病人的白细胞均提升至5.0×10 9/L以上，口腔黏膜炎1例痊愈（CR），8例好转（PR），6例稳定（NC），无1例进展（PD），总有效率（CR+PR）为60%。结论： G（M）-CSF在有效提升白细胞的同时，对同时伴有的口腔黏膜炎有明显的治疗作用。

Objective: To evaluate the efficacy of granulocyte(-macrophage) colony stimulating factor［G(M)-CSF］ in the treatment of concomitant chemoradiotherapy-induced oral mucositis in locally advanced head and neck cancer patients.Metheds: Fifteen patients with locally advanced head and neck cancer was received concomitant chemoradiotherapy,while white blood cell count were less than 1.5×10 9/L with grade Ⅲ/Ⅳoral mucositis ,they were subcutaneously given G(M)-CSF at dose of 100-300 μg daily for 3-10 days.Results: After administration of G(M)-CSF,all of the patients had an augmantation of white blood cell count more than 5.0×10 9/L. Complete healing of oral mucositis occurred in 1 patient(CR), partial in 8 patients(PR),whereas 6 patients had no change and none was progressive,the objective response rate(CR+PR) was 60%.Conclusions: G(M)-CSF is proved effective for oral mucositis caused by concomitant chemoradiotherapy in locally advanced head and neck cancer patients.