目的：探讨辅助性T细胞（Th1、Th2）在肺癌发病中的作用及其在判断预后中的意义。方法：采用酶联免疫吸附法检测血浆及胸腔积液中 γ-干扰素（IFN-γ）、白细胞介素（IL）-4水平分别反应Th1、Th2的活性；结果： 晚期肺癌患者外周血中Th1的活性较正常人低；Th1活性变化得明显。治疗不显著者Th1功能下降而Th2功能增强，生存期1年以上者Th1功能较生存期一年以下者增强，而Th2降低。结论: 外周血辅助性T细胞（Th1、Th2）的活性在肺癌患者病程及预后判断方面具有一定价值。

Objective：To investigate the effect of helper T cells (Th1 and Th2) and its important significance in judging prognosis of patients with advanced lung cancer. Methods： Interferon-γ (INF-γ) and interleukin-4 (IL-4) in plasma and pleural effusion were detected by enzyme-linked immunoassay in patients with advanced lung cancer, IFN-γ and IL-4 reflected activity of Th1 and Th2 respectively. Results： The activity of Th1 in patients with advanced lung cancer was lower than that in normal persons in peripheral blood. For non-outstanding curative effect or progressive state of illness, the activity of Th1 in patients of above 1 year survival time decreased in post-treatment than in pretreatment, the activity of Th2 increased in post-treatment. Conclusion： Activity of Helper T cells (Th1, Th2 ) could be an important marker to diagnose lung cancer and judge prognosis in patients with advanced lung cancer.