近年来，尽管恶性肿瘤的检测和治疗手段取得了长足进步，但肿瘤转移仍然是恶性肿瘤治疗失败和患者死亡的最主要原因。系统生物学和功能基因组学的发展使我们从分子水平对转移本质有了深入认识，在对肿瘤遗传异质性（tumor heterogeneity）、转移前生境（premetastatic niche）、上皮间充质转化(epithelialmesenchymal transition, EMT)

Although great achievement has been made on the diagnosis and treatment of malignant tumors, metastasis of tumor remains to be the major reason for treatment failure and death of their victims. The development of systematic biology and functional genomics give us a deeper understanding of the nature of metastasis at the molecular level. Based on the consensus reached on the metastasis mechanisms of cancer, including the genetic heterogeneity of cancer, premetastatic niche, epithelialmesenchymal transition, anoikis resistance, angiogenesis and lymphangiogenesis, etc, the targeted therapy at molecular level should be emphasized, the treatment should target the tumor stem cells, and RNAi technique and other techniques should be used in clinical antimetastatic therapy.

卫生部国家科技支撑计划项目（No.2006BAI02A00）