肿瘤的生物化疗是指肿瘤生物治疗和化学治疗的联合。肿瘤生物化疗模式一经出现，即得到迅速发展，不仅为肿瘤治疗带来了全新的治疗方法，还为恶性肿瘤的治疗领域带来了全新的治疗理念。本文就生物化疗方案适应证的扩大、生物化疗独有的“无效不更方”、靶向治疗逆转化疗耐药、生物化疗的疗效预测、免疫治疗为基础的生物化疗的最新临床研究以及生物化疗的疗效评价等方面的新进展做一综述，以期管中窥豹。

Biochemotherapy refers to the combination of biotherapy and chemotherapy, and it has been rapidly developed since its emergence. Biochemotherapy has brought both new therapies and new therapeutic ideas for the treatment of malignant tumors. In this article, we reviewed the recent advances in tumor biochemotherapies, including expansion of the indications, retaining of therapy even when tumor progressed (unique to biochemotherapy), and reversal of chemotherapy resistance by targeted therapy, the predicting response to tumor biochemotherapy, recent clinical trials of immunotherapybased chemotherapy, and evaluation criteria for assessment of biochemotherapy response, and so on.

国家“十五”重点科技攻关课题分题（No.2001BA701A15B）