免疫治疗作为一种极具发展前景的治疗方式给乳腺癌的治疗带来了新的希望。近年来，关于乳腺癌疫苗的研究已陆续开展，将这些研究成果合理、快速地用于临床，为乳腺癌的免疫治疗提供了机遇与挑战。本文重点阐述乳腺癌治疗性疫苗的一些设计策略、临床应用情况，以及未来乳腺癌疫苗研究的发展和应用趋势。随着对肿瘤特异性免疫应答的深入了解、肿瘤特异性抗原的不断发现和鉴定，以及对肿瘤微环境的深入认识，乳腺癌疫苗的研发水平必将得到进一步提高，更好地服务于临床。

Abstract Immunotherapy as a promising therapy strategy is expected to bring new hope for breast cancer treatment. Recently several breast cancer vaccines have been developed. Rational and rapid application of these scientific discoveries in clinical therapies for breast cancer patients poses great challenges and opportunities. This article is aimed to elaborate on the design strategies, current clinical trials, and future progression and application of breast cancer therapeutic vaccines. With the deepening of our understanding on the tumor-specific immune response and tumor microenvironment, and continuous discovery of new tumor-specific antigens, the research level of breast cancer vaccines will be further improved and will benefit the clinical treatment of breast cancer.

天津市科委重点项目资助(No.09jczdjc20400)