P27是近年发现的一种抑癌基因，是细胞周期蛋白依赖性激酶抑制剂（cyclindependent kinase inhibitor，CDKIs）家族成员之一。作为细胞周期负调控因子，P27蛋白具有参与细胞周期调控、诱导凋亡、促进细胞分化等多种生物学功能。许多实体瘤存在着P27基因的缺失、突变和低表达，P27的表达水平与急性白血病的发生、发展、治疗、预后密切相关。P27可应用于急性白血病的靶向治疗，通过提高P27蛋白表达水平可治疗白血病。P27基因DNA甲基化研究尚处于初始阶段，急性白血病P27 甲基化与基因表达的关系尚未明确，P27基因甲基化的改变能否作为白血病临床早期诊断及治疗的一个重要靶标，有待于深入探讨。

Biotherapy is especially beneficial for Ewing’s sarcoma with bad prognosis. The therapy includes gene therapy, immunotherapy, antiangiogenesis therapy, etc.. Gene therapy mainly refers to the application of antisense nucleic acid technique; immunotherapy refers to antibody therapy, T cell therapy, dendritic cell therapy, and tumor vaccine,etc.; and antiangiogenesis therapy refers to inhibition of tumor angiogenesis, thus suppressing tumor growth and metastasis. With the deeper understanding of Ewing’s sarcoma, changes in the telomere length, microsomal glutathione Stransferase 1 (MGST1) expression, the expression of tumor metastasis and multidrug resistance genes, and papillomavirus binding factor might serve as novel predictors for the prognosis of Ewing’s sarcoma.

昆明医学院研究生创新基金项目资助（No. KM2008L17）