肿瘤血管生成在肿瘤发生发展中起重要作用。肿瘤血管生成是一个多因素调控的复杂过程，血管内皮生长因子（vascular endothelial growth factor,VEGF）在肿瘤血管生成中起核心作用。VEGF的表达受细胞遗传特性和肿瘤微环境中众多因素的影响，涉及转录、翻译和翻译后等多个环节，但通过转录因子对VEGF的转录进行调控是其最主要途径。本文阐述了与VEGF转录关系最密切的5个转录因子（Sp1、HIF-1、AP-1、Stat3和NF-κB），并对其与肿瘤的关系进行了分析。实际上这些转录因子的下游靶标除了VEGF外，还包括其他的血管生成促进因子（如PDGF、FGF）。因此，以这些转录因子为靶标的生物治疗可能是有效的肿瘤抗血管治疗策略。

Tumor angiogenesis plays an important role in tumor development and progression, and it is a complex process regulated by many factors. Vascular endothelial growth factor (VEGF) plays a key role in the regulation of tumor angiogenesis, and it is regulated by cell genetic characteristics and many factors in tumor microenvironment at transcriptional, translation and post-translation levels, of which the regulation via transcription factor is the most important one. In this paper, we review the five most important transcription factors（Sp1，HIF-1，AP-1，Stat3 and NF-κB）and their relationship with expression of VEGF and tumors. In fact, downstream targets of these transcription factors, in addition to VEGF, also include many other angiogenesis promoting factors such as platelet-derived growth factor (PDGF) and fibroblast growth factors (FGF). Therefore, biotherapy strategy targeting these transcription factors may provide effective approaches for tumor anti-angiogenesis therapy.

国家自然科学基金资助项目(No.30901676)