近年来，趋化因子在肿瘤生长和转移中的作用引起人们的强烈关注。在多种肿瘤中（包括乳腺癌、胰腺癌、前列腺癌、结直肠癌等）发现，CXCL12/CXCR4分子对能够促进肿瘤细胞的生长，抑制肿瘤细胞的凋亡，促进肿瘤血管生成，影响某些肿瘤的靶向转移，增强肿瘤细胞的黏附和迁移能力，影响肿瘤细胞的分泌行为，提示该轴可能成为抗肿瘤药物的新靶点，具有潜在的临床应用前景。

In recent years, the role of chemokines in tumor growth and metastasis have been attracting greater attention worldwide. Studies on breast cancer, prostate cancer and pancreatic cancer have revealed that CXCL12/CXCR4 axis can increase the growth, inhibit the apoptosis, promote the angiogenesis, affect the targeted metastasis, enhance the adhesion and migration, and regulate the cytokine secretion of tumor cells, which indicates CXCL12/CXCR4 axis may be a new target for antitumor drugs and plays a potential role in clinical tumor therapy.

国家自然科学基金资助项目（No.30872303）