肿瘤免疫治疗有着与传统治疗方式不同的作用机制和疗效表现形式，因此该治疗的疗效评估是否能沿用传统治疗的评估体系是值得思考的问题，其中主要包括以下三方面的问题：一是免疫反应评价是否应被列入免疫治疗疗效评价体系？二是免疫治疗疗效评价的时间点应如何确定？三是新型免疫治疗疗效评价体系应包括哪些主要评价指标？免疫治疗在肿瘤治疗中具有越来越重要的地位，因此，尽快建立科学的评价体系对于肿瘤免疫治疗的发展和临床应用具有重要意义。

Both the mechanisms and responses of tumor immunotherapy are different from those of the traditional therapy. Therefore, whether the traditional clinical response criteria are suitable for assessing the efficacy of immunotherapy is worth exploring. First, whether the immune response should be included in the response criteria of immunotherapy? Secondly, how to determine the time point for evaluating the efficacy of immunotherapy? Thirdly, which indices should be included for the new immune-related response criteria of tumor immunotherpay? Immunotherapy is showing an increasingly important role in clinical therapy of tumor, and it is of great significance to establish a scientific response criterion system for the development and clinical application of tumor immunotherapy.

国家自然科学基金资助项目（No. 30872986/H1611）