目的：采用Meta分析方法系统评价乙型肝炎病毒（hepatitis B virus，HBV）感染与非霍奇金淋巴瘤（non-Hodgkin lymphoma，NHL）发病风险的相关性。方法：计算机检索Medline、EMBASE、PubMed、Cochrane图书馆、中国生物医学文献数据库、中国期刊全文数据库、中国科技期刊全文数据库，收集有关HBV感染与NHL发病风险相关性的病例对照研究。两名评价者独立提取纳入研究的有效信息，并使用STATA 11.0进行Meta分析。结果：共纳入15篇病例对照研究及8篇巢式病例对照研究文献。Meta分析结果显示，固定效应模型下比值比（odd radio，OR）为2.44（95% CI，2.25~2.63），随机效应模型下OR为2.49（95% CI，1.95~3.18），然而，所有的纳入研究间存在异质性（I2=86.8%，P<0.05）。亚组分析中纳入的巢式病例对照研究之间无异质性（I2=15.9%，P>0.05），随机效应模型下OR为2.16（95% CI，1.82~2.56），提示NHL患者HBV的感染率高于对照人群。结论：HBV感染可能增加NHL的发病风险，但仍需大量的实验及流行病学研究验证。

Objective:To systematically evaluate the association between hepatitis B virus (HBV) infection and non-Hodgkin lymphoma (NHL). Methods: Case-control studies on the association of HBV infection with NHL were collected from Medline, EMBASE, PubMed, the Cochrane Library, Chinese Biomedical Literature Database, Chinese Scientific Journal Full-text Database, and Chinese Journal Full-text Database. The data extraction and Meta-analysis (STATA 110) was performed by two reviewers independently. Results: 15 case-control studies and 8 nested case-control studies were included in the present study. The Meta results showed that odd radio (OR) of HBV infection in NHL when compared with the control population was 2.44 (95% CI, 2.25-2.63) in the fixed effect model and 2.49 (95% CI, 1.95-3.18) in the random effect model. There was evidence of statistical heterogeneity in all included studies (I2=86.8%，P<0.05), which disappeared in the subgroup nested case-control studies (I2=15.9%，P>0.05). OR was 2.49 (95% CI, 1.95-3.18) in the random effect model, suggesting a higher prevalence of HBV carrier state in NHL than controls. Conclusion: There is a possible causal relation between HBV infection and NHL, which needs to be confirmed by experimental and epidemiological studies.