目的：检测CXC趋化因子受体4（C-X-C chemokine receptor type 4，CXCR4）和CD40在人宫颈癌组织中的表达，并探讨两者表达水平和宫颈癌肌层浸润程度的相关性。方法：53例宫颈癌患者收集自苏州大学附属第一医院妇产科（2009年至2011年），年龄29~53岁，中位年龄41岁。免疫组织化学法检测53例宫颈癌组织中CXCR4和CD40的表达，分析两者表达水平和宫颈癌肌层浸润程度的相关性。结果：CD40和CXCR4在宫颈癌组织中有着不同程度的表达，两者间的表达水平呈正相关（P=0.035）；22例CXCR4强阳性的组织中有11例呈CD40强阳性。与CXCR4或CD40单独表达水平相比，CXCR4和CD40共表达与宫颈癌肌层浸润深度更具相关性，在CXCR4与CD40均高表达的宫颈癌组织中发生深层肌层浸润的比例高于单独高表达的宫颈癌组织（90% vs 72%，P<0.05），明显高于两者均不表达的宫颈癌组织（90% vs 20%，P<0.01）。结论：CXCR4和CD40在宫颈癌组织中的表达与宫颈癌肌层浸润程度密切相关。

Objective: To assess the expressions of CXC chemokine receptor 4 (CXCR4) and CD40 in human cervical carcinoma tissues and evaluate the correlation between their combined expression and the depth of the myometrial invasion. Methods: Fifty-three patients with cervical carcinoma aged of 29-53 years (median 41) from the First Affiliated Hospital of Soochow University were included in this study (2009-2011). The expressions of CXCR4 and CD40 in 53 cases of cervical carcinoma tissues were detected by immunohistochemistry. Then the association between the expressions of these two proteins and the depth of myometrial invasion was analyzed. Results: CXCR4 and CD40 were found to be expressed in cervical carcinoma tissues at different levels, and there was a positive correlation between CD40 and CXCR4 expressions (P=0.035). Of 22 cases which highly expressed CXCR4, 11 were found with a high expression of CD40. Furthermore, combined analysis of CXCR4 and CD40 expressions made results more relevant to the myometrial invasion. The depth of myometrial invasion was significantly higher in patients (90%) with a high expression of both CXCR4 and CD40 than in those (72%) with a high expression of one of the molecules, or those (20%) without high expressions of these two molecules (P<0.05). Conclusion: The expressions of CXCR4 and CD40 in cervical carcinoma tissues are correlated with the depth of the myometrial invasion.

国家自然科学基金资助项目（No. 81101556）；江苏省普通高校研究生科研创新计划项目资助（No.CXZZ11_0110）；苏州市科技发展计划项目(No.SYSD2011084)