目的：检测肝癌组织、癌旁组织中酪氨酸蛋白激酶ERK、C-Jun和JAK2的表达，并探讨其临床病理意义。 方法：收集武警后勤学院附属医院肝癌手术切除标本60例，采用免疫组化SP法检测ERK、C-Jun和JAK2在肝癌组织、癌旁组织中的表达；采用比例风险模型Cox进行多因素分析，探讨影响肝癌患者预后的因素。 结果： 肝癌组织中ERK、C-Jun和JAK2平均D值为（0.23±0.03）、（0.18±0.06）、（0.19±0.07），明显高于癌旁组织的\[（0.16±0.02）,（0.13±0.02）, （0.14±0.05，P<0.01\]；Cox单因素分析显示，C-Jun和JAK2与肝癌患者预后密切相关（P<0.05）；Cox多因素分析显示，JAK2是影响肝癌患者预后的重要独立因素。 结论： JAK2是影响肝癌患者预后的重要因素，可能作为判断肝癌患者预后的独立指标。

Objective : To study the clinicopathological significance of the expressions of ERK, C-Jun and JAK2 in hepatic cancer tissues and adjacent tumor tissues. Methods: The expressions of ERK, C-Jun and JAK2 in 60 hepatic cancer specimens and adjacent tumor tissues (from Department of Gastroenterology, Affiliated Hospital of Medical College of Chinese People’s Armed Police Forces) were detected by immunohistochemical SP method. A Cox multivariate analysis was performed in those patients to study the factors that influence the prognosis of hepatic cancer. Results: The average values of ERK, C-Jun and JAK2 in hepatic cancer tissues were significantly higher than that in the tumor-adjacent tissues (\[0.23±0.03\], \[0.18±0.06\], \[0.19±0.07\] vs \[0.16±0.02\], \[0.13±0.02\], \[0.14±0.05\], P<0.01). The univariate analysis results showed that the major significant prognostic factors influencing survival was the expression of C-Jun and JAK2 (P<005), and multivariate analysis revealed that the expression of JAK2 was the most important prognostic factor for hepatic cancer (P<0.05). Conclusion: The expression of JAK2 may be an prognostic factor for hepatic cancer patients.

武警后勤学院科研启动基金课题（No. WBS200814）