目的：探讨食管癌组织中P110α、pAKT的表达与食管癌临床病理特征之间的关系。 方法： 收集2010年5月至2011年5月苏州大学附属第一医院76例患者的食管癌组织标本，25例正常对照食管黏膜组织标本来自解放军第101医院病理科。免疫组织化学SP法检测食管癌及正常食管黏膜组织中P110α及pAKT的表达水平。 结果： 76例食管癌组织pAKT表达阳性率为72.4%（55/76）、P110α表达阳性率为57.9%（44/76），均明显高于对照组（PpAKT=0.001，PP110α=0.025）。食管癌组织中pAKT、P110α的高表达与食管癌淋巴结转移相关（PpAKT=0.017，PP110α=0009），与其他临床病理特征无关。食管癌组织中pAKT与P110α双阳性率为52.6%（40/76），两者的表达呈正相关（r=0.486，P=0001）。 结论：食管癌组织中P110α、pAKT表达与淋巴结转移相关，有可能成为临床检测食管癌淋巴结转移的生物指标。

Objective : To explore the relationship between the expression levels of P110α and pAKT in esophageal carcinoma (EC) tissues with clinical features of EC. Methods: EC tissues from 76 patients and esophageal tissues from 25 normal controls were collected from the Department of Pathology, No. 101 Hospital of PLA during May 2010 to May 2011. The expression levels of P110α and pAKT in EC and normal esophageal tissues were detected by SP immunohistochemistry. Results: The positive rates of pAKT and P110α in the EC group were 72.4% (55/76) and 57.9% (44/76), respectively, which were significantly higher than those in the control group（PpAKT=0.001，PP110α=0025）. The high level of protein expressions of pAKT and P110α were correlated with lymph node metastasis of EC（PpAKT=0.017，PP110α=0009). However, no correlation was found with other clinical pathological features. The double positive rate of pAKT and P110α expression in EC was 52.6% (40/76). The expression of pAKT was found in a positive correlation with P110α(r=0.486，P=0.001). Conclusion: P110α and pAKT expressions in EC are correlated with lymph node metastasis, and P110α and pAKT might be used as markers of lymph node metastasis in EC.

江苏省“六大人才高峰”项目资助（No.200967）