目的：探索阿苯达唑（albendazole）抑制结肠癌SW480细胞侵袭和迁移能力及其可能的机制。方法：体外培养人结肠癌SW480细胞，用不同质量浓度(0、1.0和2.0 mg/ml)的albendazole处理人结肠癌SW480细胞，CCK-8法检测albendazole对结肠癌SW480细胞增殖能力的影响，采用细胞划痕实验、Transwell小室实验检测细胞的迁移侵袭能力，免疫细胞化学及Western blotting检测SW480细胞中E-cadherin、MMP-2和MMP-9蛋白的表达水平。结果：与空白对照组比较，albendazole各质量浓度（1.0和2.0 mg/ml）组细胞的增殖能力明显降低，SW480细胞侵袭细胞数显著下降\[ （51.33±3.96）、（23.42±403）vs （80.76±7.18）个/视野，F=3.975, P=0.026\]；而且细胞迁移能力显著下降\[（9.6±1.13）、（6.4±0.81）vs （19.6±1.41） mm；F=5.012, P=0.023\]；E-cadherin蛋白表达水平上调，MMP-2、MMP-9蛋白表达水平明显下调。结论：Albendazole能显著抑制SW480细胞增殖，并通过上调E-cadherin的表达水平和下调MMP-2和MMP-9的分泌水平抑制细胞的侵袭和迁移能力。

Objective : To investigate the inhibitory effect of albendazole on colon carcinoma cell invasion and migration as well as the mechanisms underlying the effect. Methods: Colon carcinoma SW480 cells were treated with albendazole at 0 mg/ml, 1.0 mg/ml and 2.0 mg/ml. Cell proliferation was assessed by a cell proliferation assay using a cell counting Kit-8 (CCK-8), cell migration and invasion by wound-healing assays and transwell chamber assays, respectively, and protein levels of E-cadherin, MMP-2 and MMP-9 by immunocytochemistry and Western blotting. Results: Compared with the control (0 mg/ml), 1.0 mg/ml and 2.0 mg/ml albendazole significantly inhibited SW480 cell proliferation (P<005), and significantly decreased the invasion and migration in SW480 cells at both concentrations tested (P<0.05). Albendazole treatments significantly reduced the protein level of MMP-2 and MMP-9 but increased the protein level of E-cadherin. Conclusion: Albendazole can inhibit the invasion and migration of SW480 cells, at least partially through up-regulating the expression of E-cadherin and down-regulating the expression of MMP-2 and MMP-9.