循环肿瘤细胞（circulating tumor cell，CTC）在外周血中的存在和循环被认为是引起肿瘤远处转移的主要原因。与传统的影像学检测手段相比，CTC检测技术作为一种非侵袭性的检测手段，其操作更简便、更安全和精准。此外，CTC技术也助于研究者深入探讨肿瘤转移复发和耐药的机制。因此，CTC作为一种生物标志物，在肿瘤的早筛、早诊、预后评估和疗效检测等过程中都有着极其重要的临床意义。中科院国家纳米科学中心研发的“肿瘤捕手”技术利用多肽纳米磁珠来捕获外周血中的CTC。目前，CTC检测技术已在国内多家顶级公立医院开展临床研究和试验，大量临床数据表明，其对于肿瘤早期诊断、预后判断和耐药性监测方面具有极大的指导意义。本文就CTC的研究进展，“肿瘤捕手”技术的研发和应用作一阐述。

Existence and circulation of circulating tumor cell (CTC) in peripheral blood is recognized as a primary reason for distant metastasis of tumor. Compared with the conventional imaging diagnosed methods, CTC detection as a non-invasive detection approach is operation simpler, safer and more accurate. Moreover, CTC technique also helps researchers to explore further the mechanisms of tumor metastasis, recurrence and chemotherapy resistance. Therefore, CTC as a sensitive biomarker has important clinical significance in tumor screening, early diagnosis, prognostic evaluation and monitoring of curative efficiency. “Tumor fisher” developed by CAS is a technology which captures the CTC in peripheral blood using polypeptide nano magnetic beads. At present, the CTC detective technique has been used for clinical research and trial in many advanced public hospitals of China. A lot of clinical data indicated that this technology might have great guide significance for early diagnosis, prognostic judge and monitoring of drug resistance. The article will explain progresses of the CTC research, development and application of the “tumor fisher” technique.

国家高技术研究发展计划(No.2015AA02408）；国家自然科学基金资助项目（No. 31470049，No. 31270875）；北京市科技计划资助项目（No. 2014-2015）