目的：探讨lncRNARP5-1185K9.17在结直肠癌组织中的表达及其临床意义。 方法: 实时荧光定量-PCR法检测 2011年1月至2016年6月四川省人民医院收治的117例结直肠癌患者手术切除的癌组织及癌旁组织lncRNA RP5-1185K9.17的表达；使用Chi-Square检验、Kaplan-Meier法和Cox比例风险模型分别分析lncRNARP5-1185K9.17表达与患者临床病理特征、生存时间及预后的关系和影响结直肠癌预后的因素。 结果： lncRNA RP5-1185K9.17在结直肠癌组织中的表达明显较癌旁正常组织增高[(结肠癌: 6.850±0.420;直肠癌: 7.180±0.380) vs (癌旁组织:1.080±0.220;正常组织:0.980±0.140)，P<0.01]，lncRNARP5-1185K9.17的表达与疾病分期、淋巴结转移、远处转移、肿瘤分化和血清CEA水平及生存状态显著相关(均P<0.05)；而与患者的性别、年龄及肿瘤部位无显著关系(均P>0.05)；lncRNARP5-1185K9.17高表达患者的总生存(OS)时间及无进展生存(PFS)时间均较低表达患者明显缩短[OS:(25.45±4.28)月vs (42.69±3.72)月; PFS:(13.88±2.97)月vs (26.65±5.33)个月均<0.01]；lncRNA RP5-1185K9.17的表达、远处转移,临床分期和血清CEA水平是结直肠癌独立的预后影响因素(均P<0.05)。 结论 ：lncRNA RP5-1185K9.17可能参与调节结直肠癌的发生发展，可作为潜在的结直肠诊断和预后分子标志物。

Objective: To explore expression of long non-coding RNA (lncRNA) RP5-1185K9.17 in colorectal can-cer tissue and its clinical significance. Methods: Expression of lncRNA RP5-1185K9.17 in surgery removed cancer tissues and corresponding paracancerous tissues of the patients with colorectal cancer who hospitalized in the Sich-uan Provincial People's Hospital during January 2011 to June 2016 were detected by qRT-PCR assay. Chi-Square in-spection, Kaplan-Meier assay and Cox proportional analysis model were used respectively to analyze relationships of the lncRNA RP5-1185K9.17 expression with clinicopathological parameters, survival time and prognosis of the patients with colorectal cancer as well as factors effecting prognosis of the patients. Results: Expressions of ln-cRNA RP5-1185K9.17 in the colorectal cancer tissues were more significantly heightened than that in paracancer-ous normal tissues ([colon cancer: 6.850±0.420; rectal cancer: 7.180±0.380] vs [paracancerous tissue: 1.080±0.220;normal tissue: 0.980±0.140], P<0.01). The expression of lncRNA RP5-1185K9.17 was obviously related to TNM staging, lymph node metastasis, distant metastasis, tumor differentiation, serum CEA level and survival state of the patients (all P<0.05), but not related to gender, age and tumor location of the patients (all P>0.05). Overall survival (OS) and progression free survival (PFS) of the patients with high expression of lncRNA RP5-1185K9.17 were obvi-ously shorten than those of the patients with low expression of lncRNA RP5-1185K9.17 (OS:[25.45±4.28] month vs [42.69±3.72] months; PFS:[13.88±2.97] months vs [26.65±5.33] months, all P<0.01). Expression of lncRNA RP5-1185K9.17, distant metastasis, TNM staging and serum CEA level were independent factors effecting prognosis of the patients (all P<0.05). Conclusion: lncRNA RP5-1185K9.17 could be involved in occurrence and development of the colorectal cancer, and might be a potential molecular marker of diagnosis and prognosis of the patients with colorectal.