目的:用Meta分析法评价IL-10基因-1082A＞G位点的多态性与非霍奇金淋巴瘤(non-Hodgkin lymphoma，NHL)易感性的相关性。 方法: 利用计算机检索PubMed、EMBASE、Web of Science、中国生物医学文献数据库、中文科技期刊全文数据库、中国期刊全文数据库和万方数据库，检索日期自各数据库建库到2017年1月止，全面检索IL-10基因-1082A＞G位点的多态性与NHL易感性的病例对照研究文献, 采用STATA 12.0统计软件进行Meta分析。 结果: 最终纳入16篇病例对照研究文献进行Meta分析，共计4 718例NHL患者和3 877例健康对照人员。分析结果显示，IL-10基因-1082A＞G位点在等位基因模型(A vs G: OR=1.12, 95% CI=1.04～1.21)、共显性模型(AA vs AG: OR=1.27, 95% CI=1.06～1.52)、相加模型(AA vs GG: OR=1.22, 95% CI=1.06～1.40)和显性模型 (AA vs AG+GG: OR=1.29, 95% CI=1.08～1.53) 下与NHL易感性有关；而在隐性模型(GG vs AA+AG: OR=1.11,95% CI=0.92～1.34)与NHL易感性无关。 结论： IL-10基因-1082A＞G位点多态性可能与NHL易感性相关。

Objective: To assess the association between interleukin-10 (IL-10) gene -1082A＞G polymorphism and non-Hodgkin lymphoma (NHL) susceptibility using Meta-analysis. Methods: Case-control studies about IL-10 gene -1082A＞G polymorphism and NHL susceptibility were searched in PubMed, EMBASE, Web of Science,Chinese Biomedical Literature Database, Chinese Science and Technology Academic Journal, Chinese Journal Full-text Database and Wanfang Database from their inception toJanuary 2017. Meta-analysis was performed using STA-TA 12.0 software. Results: A total of 16 case-control studies were included in this Meta-analysis, including 4 718cases and 3 877 controls. There was association between IL-10 gene -1082A＞G polymorphism and NHL suscepti-bility inallele genetic model (Avs G: OR=1.12, 95%CI=1.04-1.21)，codominant model (AA vs AG: OR=1.27, 95%CI=1.06-1.52) ，additive model (AAvsGG:OR=1.22,95%CI=1.06-1.40) and dominant model (AA vs AG+GG: OR=1.29, 95%CI=1.08-1.53)，but no association with NHL susceptibility in recessive model (GG vs AA+ AG:OR=1.11,95%CI=0.92-1.34). Conclusion: IL-10 gene -1082A＞G polymorphismmay be associated with NHL Susceptibility.