目的：探讨核磷蛋白(nucleophosmin, NPM、B23、NO38或NPM1)在鼻咽癌活检组织中的表达水平与增殖指数和患者个体化治疗后疗效的关系。方法：随机选取中山大学肿瘤防治中心2001年1月1日至2003年12月31日期间收治的157例初诊鼻咽癌患者的治疗前活检蜡块，用免疫组织化学法检测鼻咽癌活检组织中NPM1 和Ki67 的表达，并结合相应临床病理资料，应用统计学方法对结果进行分析。结果：NPM1 的表达水平与Ki67的表达水平呈正相关(r=0.445, P<0.01)，与淋巴结分期呈负相关(N0, N1, N2和N3; r=-0.235，P<0.01)，但与原发灶分期(T1, T2, T3 和T4; r=0.006, P>0.05) 和临床分期(r=-0.74, P>0.05)无相关性。NPM1表达水平与有淋巴结转移组治疗后淋巴结情况呈负相关(r=-0.196, P<0.05)，与无淋巴结转移组治疗后原发灶情况呈负相关(r=-0.349，P<0.05)。NPM1表达水平与预后无明显相关性。结论：NPM1 在鼻咽癌组织中高表达并与Ki67 的表达水平呈正相关，NPM1有促进细胞增殖的作用且可能作为一个评估个体化治疗疗效的评价指标。

Objective: To investigate the relationship between nucleophosmin (NPM, B23, NO38 or NPM1) expression levels in tumor biopsy tissues as well as the proliferation index and the therapeutic efficacy in nasopharyngeal carcinoma (NPC) patients. Methods: One hundred and fifty- seven nasopharyngeal carcinoma patients, who were treated at Department of Pathology, Sun Yat-sen University cancer center during the period from January 1, 2001 till December 31, 2003 with preserved pre-treatment paraffin-embedded biopsy blocks, were randomly selected. The expressions of Ki-67 and NPM1 in the 157 sample tissues were determined by immunohistochemistry, respectively.The clinical data of patients were reviewed in detail, and the SPSS-16 soft ware was adopted for statistical analysis.Results: The levels of NPM1 were positively correlated with Ki-67 expression (r=0.445, P<0.01), but negatively correlated with regional lymph node status (N0, N1, N2, and N3; r=-0.235, P<0.01); however, it’s not correlated with primary tumor staging (T1, T2, T3 and T4; r=0.006, P>0.05) or clinical staging (r=-0.74, P>0.05). The expression of NPM1 was negatively correlated with the palpable rate of lymph node(s) (r=-0.196, P<0.05) in lymph node metastasis group, and negatively correlated with the primary lesion status after treatment (r=-0.349, P<0.05)in lymph node non-metastasis group. NPM1 expression was not significantly correlated with of the prognosis of patients. Conclusion: NPM1 expression in nasopharyngeal carcinoma tissues was positively correlated with Ki67 expression, proving NPM1 could promote the cell proliferation and might be used as an indicator for predicting the efficacy of individualized therapy for nasopharyngeal carcinoma patients.