[摘 要] 多形性成胶质细胞瘤（glioblastoma multiforme，GBM）是最常见的中枢神经系统恶性肿瘤，传统的治疗手段如手术、放 疗和化疗等虽然不断进步，但依然预后不佳。上皮-间质转化（epithelial-interstitial transformation，EMT）是上皮细胞来源的恶性肿 瘤获得侵袭和迁移能力的重要病理过程，与GBM的侵袭、迁移及放化疗耐受性等恶性生物学行为密切相关。本文将聚焦EMT 相关病理生理过程及其与GBM侵袭和转移行为相关的最新进展，阐述EMT在GBM中的基因调控与分子信号通路，如金属基质 蛋白酶、TGF-β和转录因子Snail、Twist等，从而为GBM研究提供新的思路。

[Abstract] Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system. Despite advances in traditional treatment strategies that combine surgery with radiotherapy and chemotherapy, GBM remains one of the most lethal diseases with dismal prognosis. Epithelial-interstitial transformation (EMT) is an important biological process for the invasion and migration of malignant tumors derived from epithelial cells, which is closely related to the pathological behaviors of GBM including invasion, migra- tion, resistance to chemotherapy and radiotherapy. This review will introduce the concept of EMT and its pathophysiological process, especially the latest findings related to the GBM biology. Besides, gene regulation and signaling pathways of EMT (such as matrix me- talloproteinases [MMP], TGF-β, transcription factors Snail and Twist etc.) participated in GBM are also introduced, thereby providing a new insight into the fundamental researches and clinical treatments of GBM.

国家十三五计划科技支撑计划课题子课题资助项目 （No. 2016YFC1301800）