目的:用Meta 分析的方法评价IL-17 基因rs763780 位点的多态性与胃癌易感性的相关性。方法: 计算机检索PubMed、EMBASE、The Cochrane Library、Web of science、万方数据库、中国生物医学文献数据库、中文科技期刊数据库、中国期刊全文数据库，检索日期自各数据库开始建库至2017 年12 月，全面检索IL-17 基因rs763780 位点的多态性与胃癌易感性的病例对照研究文献，采用STATA 12.0 统计软件进行Meta 分析。结果: 最终纳入10 篇病例对照研究文献，共计3 892 例胃癌患者和4627 例健康对照。Meta 分析结果显示，IL-17 基因rs763780 位点多态性在等位基因模型(C vs T：OR=1.90, 95% CI=1.73～2.08)、相加模型(CC vs TT：OR=1.76, 95% CI=1.45～2.14)、共显性模型(CC vs CT：OR =1.26, 95% CI=1.13～1.42)、显性模型（CC vs CT+TT：OR=1.93, 95% CI=1.65～2.26）及与隐性模型（TT vs CT+CC：OR =1.67, 95% CI=1.38～2.03）下均与胃癌的易感性相关。结论：IL-17 基因rs763780位点多态性增加了胃癌的发病风险。

Objective: To assess the association between interleukin-17 (IL-17) gene rs763780 polymorphism and susceptibility of gastric cancer using Meta-analysis. Methods: A comprehensive search was performed on PubMed, EMBASE, the Cochrane Library, Web of Science, Wanfang Database, Chinese Biomedical Literature Database, Chinese Science and Technology Academic Journal and Chinese Journal Full-text Database from their inception to December 2017 to identify relevant case-control studies on association between interleukin-17 (IL-17) gene rs763780 polymorphism and susceptibility of gastric cancer. Meta-analysis was performed using STATA 12.0 software. Results: A total of 10 case-control studies were included in this Meta-analysis, involving 3 892 gastric cancer cases and 4 627 controls. The results showed that there was association between IL-17 rs763780 polymorphism and gastric cancer risk in allele genetic model (C vs T: OR=1.90, 95% CI=1.73-2.08), additive model (CC vs TT: OR=1.76, 95% CI=1.45-2.14), codominant model (CC vs CT: OR =1.26, 95% CI=1.13-1.42), dominant model (CC vs CT+TT: OR=1.93, 95% CI=1.65-2.26) and recessive model (TT vs CT+CC: OR=1.67, 95% CI=1.38-2.03). Conclusion: IL-17 rs763780 polymorphism increases the risk of gastric cancer.