[摘要] 目的：探讨生存素（survivin）、纤连蛋白-1（fibronectin-1）、血管内皮生长因子(VEGF)和埃兹蛋白（ezrin）在甲状腺肿瘤组织中的表达变化及其与肿瘤病理特征的关系。方法：选取遵义医科大学第三附属医院暨遵义市第一人民医院2016 年10 月至2018 年10 月接诊的90 例甲状腺肿瘤患者纳入肿瘤组，选择同期健康体检经病理证实为正常甲状腺的人群75 例为对照组，应用免疫组化法检测survivin、fibronectin-1、VEGF 与ezrin 蛋白水平。结果：对照组survivin 蛋白阳性率为2.67%，低于观察组的97.78%；对照组fibronectin-1 蛋白阳性率为4.00%，低于观察组的96.67%；对照组VEGF 蛋白阳性率为1.33%，低于观察组的93.33%；对照组ezrin 蛋白阳性率为1.33%，低于观察组的95.56%，差异均有统计学意义（P<0.05 或P<0.01）。Survivin、fibronectin-1、VEGF与ezrin 蛋白表达量与TNM分期、肿瘤直径、甲状腺外侵犯、淋巴转移情况存在明显相关性（均P<0.05）。结论：Survivin、fibronectin-1、VEGF与ezrin 蛋白均参与了甲状腺肿瘤的发生和发展，上述4 项指标联合检测对于甲状腺肿瘤的诊断、治疗、判断预后均有重要意义。

[Abstract] Objective: To investigate the expression of survivin, fibronectin-1, vascular endothelial growth factor (VEGF) and ezrin in thyroid tumors and their relationship with the pathological characteristics of thyroid tumors. Methods: Ninety patients with thyroid tumors admitted to the third affiliated hospital of Zunyi Medical University and the first hospital during Oct. 2016 and Oct. 2018 were selected as the observation group. Seventy-five patients with normal thyroid confirmed by pathology in the same period were selected as the control group. The protein levels of survivin, fibronectin-1, VEGF and ezrin were detected by immunohistochemical method.Results: The positive rates of survivin, fibronectin-1, VEGF and Ezrin in the control group were 2.67%, l4.00%, 1.33% and 1.33%,which were lower than 97.78%, 96.67%, 93.33% and 95.56% in the observation group, respectively (all P<0.05 or P<0.01). The expressions of survivin, fibronectin-1, VEGF and ezrin were significantly correlated with TNM staging, tumor diameter, extrathyroid invasion and lymphatic metastasis (all P<0.05). Conclusion: Survivin, fibronectin-1, VEGF and ezrin proteins are all involved in the occurrence and development of thyroid tumors. The combined detection of these four indicators is of great significance in the diagnosis, treatment and prognosis of thyroid tumors.

贵州省科学技术基金资助项目（No. 2017-1210）