慢性非可控性炎症在肝细胞癌（hepatocellular carcinoma，HCC）发生过程中发挥关键作用。在慢性病毒性肝炎、酒精性肝炎和非酒精性脂肪性肝炎等HCC发生危险因素中，慢性非可控性炎症的发生发展是HCC发生的核心因素。在慢性炎症发生发展过程中，损伤或死亡的肝细胞能够介导肝脏中的免疫细胞活化，进而促发炎症，迁延不愈的肝脏炎症促进了肿瘤的发生；其中肝细胞的损伤或死亡方式和不同免疫细胞活化导致的炎症进展在HCC发生中的作用不尽相同，涉及肝损伤、炎症和代偿性增殖等多个病理或病理生理过程，以及多种细胞、信号通路和调控分子的功能改变。深入研究肝脏炎癌转化的调控机制有助于为HCC发生的干预提供理论基础。本文就肝脏炎癌转化及其调控机制的研究进展作一综述

Uncontrolled chronic inflammation plays key roles in the carcinogenesis of hepatocellular carcinoma (HCC). Among the risk factors of HCC, such as chronic viral hepatitis, alcoholic hepatitis, non-alcoholic steatohepatitis and so on, the occurrence and development of uncontrolled chronic inflammation are the core factors of HCC. The damaged or dead hepatocytes generated during the process of chronic inflammation may lead to the activation of immune cells in the liver, resulting in hepatic inflammation. Chronic and prolonged liver inflammation promotes the occurrence of cancer. During this process, different injuries or death patterns of hepatocytes and progression of inflammation caused by activation of different immune cells play different roles in hepatic carcinogenesis, involving multiple pathological or pathophysiological processes such as liver injury, inflammation, and compensatory proliferation, as well as function alteration of various cells, signaling pathways, and regulatory molecules. Further studies on the regulatory mechanisms of hepatic inflammation-induced carcinogenesis are helpful to provide theoretical basis for the intervention of occurrence of HCC. This review focused on the research progress of regulatory mechanisms involved in the hepatic inflammation-induced carcinogenesis.

国家自然科学基金重大研究计划项目（No. 91842104）