精准检测技术推动了精准医学时代个体化肿瘤诊治的发展，同时，临床精准诊治的需求进一步驱动精准检测技术的 改良与应用。近年来，精准医学检测实现了从基因低通量测序到高通量测序、组织活检到液体活检及多细胞混杂检测到单细胞 精准检测的变革，推动了肿瘤精准医学时代新技术、新靶点、新药物的产生与发展。未来，多维度联合检测有助于提高精准医学 的精准度，ctDNA甲基化检测分析则有助于拓宽精准医学研究领域，临床试验设计的变革也有助于推动精准医学深入发展。

Precision detection techniques have promoted the development of individualized diagnosis and treatment of tumors in the era of precision medicine. At the same time, clinical demands of precision treatments have further driven the development and application of precision detection techniques. In recent years, precision medical detection techniques realized rapid transformations from low-throughput to high-throughput genomic sequencing, from tissue biopsies to liquid biopsies, and from multicell promiscuous detection to single cell precision sequencing. All these changes have promoted the emergence and development of new technologies, new targets, and new drugs in the era of precision oncology medicine. In the future, multi-dimensional combined detection could help to improve the accuracy of precision medicine; ctDNA methylation detection analysis could broaden the research field of precision medicine; and the transformation of clinical trial design could also contribute to promote the in-depth development of precision medicine.

国家重点研发项目（No. 2016YFC1303804）；吉林省科技厅科技发展计划项目（No. 20190303146SF）；吉林省发展和改革委 员会省级产业创新专项资金项目（No. 2017C022）；吉林省科技厅重点实验室建设项目（No. 20170622011JC）