遗传基因的表达和调控决定了机体的衰老过程。一般认为，衰老是一个不可逆的过程。随着年龄的增长，机体各器官包括免疫系统均会出现衰老的现象，而免疫衰老又会继发多种与年龄相关的疾病，例如肿瘤、心血管疾病、阿尔茨海默病和骨质疏松等。这些疾病直接或间接地影响了人们的生活质量和寿命。如何延缓衰老、维护免疫功能、保持健康已成为社会关注的热点。本文将从机体衰老、免疫衰老、免疫衰老相关疾病、衰老与肿瘤治疗和抗衰老与疾病治疗等方面，探讨衰老与相关疾病、抗衰老的机制及其防治。

Expression and regulation of genetic genes determine the senescent process. Generally, aging has been regarded as an irreversible process. Along with age increasing, each organ of the body including immune system experiences senescence. Immunosenescence promotes the age-related diseases, such as tumor, cardiovascular diseases, Alzheimer's disease, osteoporosis, and so on. These diseases seriously affect the quality of human life and longevity. How to delay senility, maintain immune function, and keep a good health have become the hot points of social concerns. In this review, by discussing the aging, immunosenescence and its related diseases,aging and tumor treatment as well as anti-aging and disease treatment etc, we explore the mechanisms, prevention and treatment of senescence, senescence-related disease and anti-aging.

国家自然科学基金资助项目(No.31471339)；国家科技重大专项资助项目（No.2018ZX10302207-003-003）