环境因素是诱发肺癌的一个重要危险因素，吸烟者患肺癌的风险是非吸烟者的20倍。然而，仅有不到20%的吸烟者 患肺癌。近年来，多项研究表明遗传多态性在肺癌发病风险差异中发挥重要作用，主要涉及基因单核苷酸多态性和低频高外显 突变，对其深入探究可筛选肺癌易感基因和遗传高危人群，提供遗传咨询，并为临床精准诊疗提供依据。本文主要从肺癌遗传易 感性及高危人群筛查、早期肺癌诊断及晚期肺癌精准诊疗三方面内容进行概述。

Environmental factors are important risk factor for lung cancer. Smokers are 20 times more likely to develop lung cancer than non-smokers. However, less than 20% of smokers develop lung cancer. In recent years, many studies have shown genetic polymorphism plays an important role in the development of lung cancer, mainly involving single nucleotide polymorphisms and rare highexogenous mutations. The in-depth research of the gene polymorphism will be beneficial to the screen of susceptible genes in lung cancer and genetically high-risk population, providing genetic counseling and evidence for clinically precise diagnosis and treatment. This article mainly summarizes the contents regarding genetic susceptibility of lung cancer and high-risk population screening, early diagnosis of lung cancer as well as precise medication of advanced lung cancer.

吉林省财政厅嵌合抗原受体（CAR）免疫细胞技术研发项 目资助（No. 2018SCZWSZX-010）；吉林省科技厅科技发展计划资助项 目（No. 20190303146SF）；吉林省发展和改革委员会省级产业创新专项 资金项目（No. 2017C022）；吉林省科技厅重点实验室建设项目资助(No. 20170622011JC)