目的： 通过Meta分析的方法评价抗生素对免疫检查点抑制剂治疗非小细胞肺癌（non-small lung cancer, NSCLC）疗效的影响。方法： 检索Pubmed、Cochrane Library、EMbase、EBSCO循证医学数据库、中国生物医学文献数据库（CBM）、中国知网（CNKI）中收录的关于抗生素对免疫检查点抑制剂治疗NSCLC疗效影响的相关文献，采用RevMan 5.3软件对疗效进行Meta分析。结果： 纳入14篇文献共2 505例NSCLC患者，Meta分析结果显示，抗生素的应用可显著缩短免疫检查点抑制剂治疗NSCLC患者的PFS（HR=1.14，95%CI=1.04-1.26，P=0.005）和OS（HR=1.30，95%CI=1.14-1.47，P<0.0001）。结论： 免疫检查点抑制剂治疗NSCLC之前、同步或之后应用抗生素可能显著缩短PFS和OS，对疗效有可能产生不利影响。

Objective: To investigate the effects of antibiotics on the treatment efficacy of immune checkpoint inhibitors in NSCLC (non-small cell lung cancer) with Meta-analysis.Methods: Literatures regarding the effects of antibiotics on the treatment efficacy of immune checkpoint inhibitors in NSCLC were searched in Pubmed, Cochrane Library, Embase, EBSCO, Chinese Biomedical Literature Database(CBM) and Chinese Journal Full-text Database(CNKI). RevMan 5.3 software was used in this Meta-analysis.Results: Fourteen articles involving 2 505 NSCLC patients were included in this study. Meta-analysis showed that the application of antibiotics could significantly shorten the PFS (HR=1.14, 95%CI =1.04-1.26, P=0.005) and OS (HR=1.30, 95%CI =1.14-1.47, P<0.0001) of NSCLC patients treated with immune checkpoint inhibitors.Conclusion: Application of antibiotics before, concurrently or after immune checkpoint inhibitors in the treatment of NSCLC may significantly shorten PFS and OS, resulting in adverse effect on treatment efficacy.

R734.1

天津市科学技术委员会重大项目（No. 18ZXDBSY00050）