代谢重编程是肿瘤的特征之一，也是肿瘤治疗的重要潜在靶点。肿瘤和免疫细胞之间的相互作用对代谢重编程的影响是决定抗肿瘤免疫应答的关键因素之一。肿瘤代谢不仅在肿瘤发生和维持肿瘤细胞生存中发挥了关键作用，并且可以通过释放代谢产物，如乳酸、PGE2等来影响免疫细胞进而影响肿瘤免疫微环境。这种肿瘤细胞与免疫细胞之间的相互作用导致了肿瘤免疫微环境中的代谢竞争，限制了营养物质的正常代谢，形成酸性环境，最终导致抗肿瘤免疫反应减弱和免疫抑制性微环境的形成。此外，免疫细胞发生免疫应答的过程中存在代谢方式的改变，即在增殖、分化和执行细胞功能的过程中会发生代谢重编程。因此，了解肿瘤免疫微环境中肿瘤细胞和免疫细胞的代谢重编程的调节机制，可以使研究人员在抗肿瘤免疫治疗中获得靶向代谢途径的治疗思路。

Metabolic reprogramming is one of the characteristics of tumors and an important potential target for tumor therapy. The effect of the interaction between tumor and immune cells on metabolic reprogramming is one of the key factors determining the anti-tumor immune response. Tumor metabolism not only plays a key role in maintaining tumor genesis and survival, but also affects immune cells by releasing metabolites such as arginine and PGE2, thereby affecting the tumor immune microenvironment. The interaction between tumor cells and immune cells leads to metabolic competition in the tumor immune microenvironment, which limits the normal metabolism of nutrients and forms an acidic environment, and ultimately leads to a weakened anti-tumor immune response and the formation of an immunosuppressive microenvironment Moreover, there are alterations in metabolism of immune cells during the process of immune responses, that is metabolic reprogramming occurs in immune cells during their proliferation, differentiation and performance of cellular functions. Therefore, understanding the regulatory mechanism of metabolic reprogramming of tumor cells and immune cells in tumor immune microenvironment will enable researchers to find therapeutic means of targeting metabolic pathways in anti-tumor immunotherapy.

R730.4；R730.3

国家自然科学基金面上项目（No. 82173198；No. 81872143）