细胞因子作为抗肿瘤免疫中的重要一环，曾是肿瘤免疫疗法中的一颗闪耀的明星。站在肿瘤免疫治疗策略转换的时代潮头，肿瘤免疫细胞因子综合治疗通过理论创新、技术革新和多种优化组合，不断迭代和探索，逐步改变了肿瘤免疫单药治疗效果不尽如人意的局面，从而再创辉煌，为肿瘤的综合免疫治疗提供了新的方式。对肿瘤微环境细胞间通讯方式的新认识、肿瘤免疫新型细胞因子和新型修饰产品等的研发、共享信号受体独特结构的发现以及与新一代抗肿瘤治疗手段的联合等为肿瘤细胞因子疗法的应用注入了新的活力。这些发展彰显了“创新与联合”在肿瘤免疫细胞因子综合治疗策略设计中的指导作用，对于其他肿瘤生物治疗技术的研发也具有一定的参考价值。

As an important part of anti-tumor immunity, cytokines were once shining stars in tumor immunotherapy. Standing at the tide of the transformation of cancer immunotherapy strategy, comprehensive cytokine-based cancer immunotherapy has continuously iterated and explored through a variety of the theoretical and technological innovations as well as various optimized combinations, and gradually changed the unsatisfactory effect of tumor monotherapy, so as to create another brilliance and provide a new way for comprehensive tumor immunotherapy. The new understanding of the intercellular communication in tumor microenvironment, the research and development of novel cytokines and modified products for tumor immunity, the discovery of the unique structure of shared signaling receptors and the combination with the new generation of anti-tumor treatment have injected new vitality into the application of tumor cytokine therapy. These findings highlight the guiding role of "innovation and combination" in the design of comprehensive strategy of cytokine-based cancer immunotherapy, and also have a certain reference value for the research and development of other tumor biotherapy technologies.

R730.51

国家自然科学基金重点项目资助（No. 81730039）