目的：探讨2009—2021年间国内外学者关于干扰素基因刺激因子（STING）信号通路在乳腺癌进展中的研究现状、合 作情况、研究热点及发展趋势。方法：以Web of Science数据库检索乳腺癌和STING作为关键词的122篇核心合集文献作为研 究对象，应用Citespace可视化分析软件评估STING调控乳腺癌发展中的作用。结果：以2016年为时间节点，乳腺癌与STING相 关的研究发文量迅速增加，其中美国发文量最多，丹娜法伯癌症研究院为排名第一的研究机构。DNA断裂过程中产生的微核激 活了cGAS-STING信号通路，可有效启动肿瘤特异性CD8+ T细胞的抗肿瘤作用。关键词聚类分析和研究热点及发展趋势分析结 果也表明，以巨噬细胞为代表的抗肿瘤免疫治疗是乳腺癌与STING相关研究领域的热点问题。结论：STING信号通路中的关键 分子将成为乳腺癌防治领域的新免疫靶点。

Objective: To explore the current status, collaboration, hotspots and development trends of domestic and international researches on stimulator of interferon genes (STING) signaling pathway in breast cancer progression from 2009 to 2021. Methods: Using "breast cancer" and "STING" as key words, 122 research papers from core collections were retrieved from Web of Science database and subject to visualization analysis by Citespace software to evaluate the role of STING in regulating breast cancer progression. Results: Since 2016, research papers related to breast cancer and STING have increased rapidly, among which the greatest number of publications came from the United States, with Dana-Farber Cancer Institute ranking the first. Micronuclei produced in DNA strand breakage stimulate the cGAS-STING signaling pathway and can effectively initiate tumor-specific CD8+ T cell anti-tumor immune responses. Key word cluster analysis and analysis of research hotspots and development trends also indicate that anti-tumor immune therapies represented by macrophages are the hot issue in breast cancer and STING related research field. Conclusion: Key molecules in STING signaling pathway will become a new immune target for prevention and treatment of breast cancer.

国家自然科学基金资助项目（No.81960554）