细胞焦亡是近年来发现的一种全新的调节性细胞死亡形式，在肿瘤免疫中发挥重要作用。肿瘤发生发展进程中的细 胞焦亡包含免疫细胞焦亡（ICP）和肿瘤细胞焦亡（CCP）两种类型，并可能发挥促癌或抑癌作用。Caspase-1介导的经典途径和 caspase-4/5/11介导的非经典途径均可以介导ICP的发生，ICP参与的肿瘤免疫中，炎症小体和细胞因子IL-18、IL-1β发挥了重要 作用。Caspase-3和颗粒酶B切割并激活GSDME途径介导了CCP的发生，在肿瘤发生过程中自发且持久的CCP促进肿瘤生长， 而在化疗等过程中GSDME激活介导的CCP则具有显著的抑癌作用。细胞焦亡的发生可以刺激肿瘤微环境中的炎症反应，提高 肿瘤细胞的免疫原性，促进抗肿瘤免疫的发生。因此，细胞焦亡及其引发的炎症反应在肿瘤免疫中发挥重要作用，对该领域的研 究可能为抗肿瘤免疫治疗提供新思路。

Pyroptosis is a recently-discovered novel regulatory cell death that plays an important role in tumor immunity. Pyroptosis in cancer progression includes immune cell pyroptosis (ICP) and cancer cell pyroptosis (CCP), which may promote or inhibit cancer. The occurrence of ICP can be mediated by both caspase-1 mediated classical pathway and caspase-4/5/11 mediated non-classical pathway. Inflammasome and cytokines IL-18 and IL-1β play important roles in tumor immunity involving ICP. The occurrence of CCP is mediated by GSDME pathway which can be cleaved and activated by caspase-3 and granzyme B. Spontaneous and persistent CCP promotes tumor growth during tumorigenesis, while GSEME activation-mediated CCP has significant anti-tumor effect during chemotherapy and other processes. Pyroptosis can stimulate inflammatory response in tumor microenvironment, improve immunogenicity of tumor cells and promote the occurrence of anti-tumor immunity. Therefore, pyroptosis and its induced inflammatory response play an important role in tumor immunity. Researches in this field may provide new ideas for anti-tumor immunotherapy.

国家自然科学基金面上项目资助（No.81872236）；天津市重大疾病防治科技重大专项资助项目（No.18ZXDBSY00040）