目的：探讨乳腺癌特异基因1（BCSG1）与Hsa-circ-0026352 在浸润性乳腺癌（IBC）遗传易感性中的交互作用。方法：选取2019 年6月至2022 年5月间武汉市中西医结合医院收治的100 例IBC 患者作为研究对象，采用免疫组化法检测IBC 组织及其相应癌旁组织中BCSG1的表达，将研究对象按照IBC 组织中BCSG1蛋白表达的高低分为阴性、弱阳性和强阳性组，统计三组患者的临床病理特征及雌激素受体（ER）、孕激素受体（PR）、表皮生长因子受体-2（HER2）、Hsa-circ-0026352 的表达情况，采用Logistic 回归方程和最大似然法分析BCSG1表达与上述参数的趋势性和交互作用。结果：与癌旁组织比较，IBC 组织中BCSG1蛋白呈高表达（P<0.05）；BCSG1蛋白强阳性表达与淋巴结转移、分化程度、临床分期、HER2表达、 Hsa-circ-0026352 表达有关联（P<0.05）；BCSG1强阳性表达与IBC存在交互作用（P<0.05）；BCSG1表达与IBC的交互作用在Hsa-circ-0026352 阳性表达中最为显著（趋势P<0.001）；BCSG1表达与IBC 的交互作用在临床分期Ⅲ期、低分化程度中最为显著（趋势P<0.001）。结论：BCSG1与IBC患病密切相关，且与Hsa-circ-0026352、临床分期、分化程度存在交互作用，可共同增加IBC患病风险性。

Objective: To investigate the interaction between breast cancer specific gene 1 (BCSG1) and Hsa-circ-0026352 in genetic susceptibility of invasive breast cancer (IBC). Methods: 100 IBC patients admitted to Wuhan Hospital of Integrated Traditional Chinese and Western Medicine between June 2019 and May 2022 were selected as the study subjects, and the expression of BCSG1 in IBC tissues and their corresponding paracancerous tissues was detected by immunohistochemistry. The study subjects were classified into negative group, weakly positive group, and strongly positive group according to their protein expression level of BCSG1 in IBC tissues. The clinicopathological characteristics and expression of estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor-2 (HER-2) and Hsa-circ-0026352 of the patients in three groups were counted, and the trends and interactions of BCSG1 expression with the above parameters were analyzed using Logistic regression equations and maximum likelihood method. Results: The protein expression of BCSG1 was significantly higher in IBC tissues compared with the paracancerous tissues (P<0.05). Strong positive BCSG1 protein expression was associated with lymph node metastasis, differentiation degree, clinical stage, HER2 expression, and Hsa-circ-0026352 expression (all P<0.05). There was an interaction between strong positive BCSG1 expression and IBC (P<0.05). The interaction between BCSG1 expression and IBC was most significant in patients with positive Hsa-circ-0026352 expression (P<0.001). The interaction between BCSG1 expression and IBC was most significant in patients with clinical stage Ⅲ and low differentiation (all P<0.001). Conclusion: BCSG1 is closely related to IBC and interacts with Hsa-circ-0026352, clinical stage and degree of differentiation, which can collectively increase the risk of IBC.

武汉市卫生计生科研基金（No. WX19Z3）