N7-甲基鸟苷（m7G）是表观遗传学调控过程中最常见的RNA 修饰之一，在mRNA、核糖体RNA（rRNA）、转运RNA （tRNA）、miRNA 等多种RNA分子的加工和代谢中起着重要作用，进而参与细胞增殖、分化、凋亡和迁移等多种功能。越来越多的证据表明，m7G甲基化修饰参与肿瘤的发生发展。异常的m7G甲基化修饰通过调控癌基因和抑制基因的表达促进或抑制多种肿瘤的进展，m7G甲基化修饰及其调控因子可能是肿瘤诊断和治疗的潜在靶点。本文就m7G甲基化修饰的最新研究进展、检测方法及其在肿瘤发生发展中作用的分子机制进行评述。

RUNX, a member of transcription factor family, plays an important role in the regulation of mammalian cell proliferation, differentiation, lineage development, osteogenesis and neurogenesis. The studies of RUNX have revealed the diversity of its function and its role in tumor genesis and progression. RUNX family members have different functional manifestations in different types of tumors and have different levels of association with various components in the tumor microenvironment. RUNX family members regulate the lineage development and differentiation of CD4+ helper T (Th) cells and CD8+ cytotoxic T lymphocytes (CTLs) in the tumor microenvironment, modulate the phenotype, differentiation, and survival of tissue-resident T-lymphocytes, and drive the proliferation activation and tissue-resident of NK-cells. RUNX family deletion leads to MDSC proliferation and maturation activation, which induces a tumor immunosuppressive icroenvironment. The expression of RUNX family members also significantly correlates with the degree of infiltration of tumor-associated fibroblasts (CAFs) in the tumor microenvironment, the infiltration of different immune cells, immune checkpoint gene expression, and drug sensitivity, which could serve as potential prognostic markers of tumors and as targets for tumor immunotherapy, and the combination with CAR-T cell therapy has great potential for application. This review focuses on the basic structure and function of RUNX and its role in the regulation of various components in tumor immunity and microenvironment, aiming to provide a new perspective for tumor immunotherapy with RUNX as the main target in the future.

国家自然科学基金（No. 32270955，No. 81972869）；江苏省重点研发计划专项资金项目（No. BE2022719）；江苏省自然科学基 金（No. BK20211065）；江苏省医学重点学科基金（No. YXZDXK202236）；江苏省研究生科研与实践创新计划（No. KYCX23_3265）；常州市卫生健康 委员会重大科技项目（No. ZD202329）；常州市卫生健康委员会青苗工程项目（No. CZQM2020044）