[摘 要] 免疫细胞介导的药物递送系统是以免疫细胞为载体，利用细胞固有的趋化作用将治疗药物靶向递送至特定病灶部位， 因其具有优异的生物相容性、低免疫原性、组织特异性归巢及易穿过生物屏障等多重优势，已成为药物递送和疾病治疗的重要手 段。本文系统论述免疫细胞的载药策略和单核细胞、中性粒细胞、间充质干细胞和树突状细胞等作为载体细胞的生物学特性、主 要优缺点，以及应用于肿瘤治疗的最新研究进展，为深入研究免疫细胞介导的药物递送系统和临床转化提供重要参考。

[Abstract] Immune cell-mediated delivery system employs immune cells as carriers to deliver therapeutic drugs to specific lesion sites by leveraging the innate chemotaxis of these cells. Due to its excellent biocompatibility, low immunogenicity, tissue-specific homing, and ability to cross biological barriers, this approach has emerged as an important strategy for drug delivery and disease treatment. This article systematically discusses the drug delivery strategies of immune cells, the biological characteristics, advantages, and disadvantages of using monocytes, neutrophils, mesenchymal stem cells, and dendritic cells as carrier cells, as well as the latest research progresses on their application in tumor treatment. This review provides valuable insights for further studies on immune cell-mediated drug delivery systems and their clinical transformation.

国家自然科学基金重点项目（No. 82130050，No. 82330053）