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Treatment of Myelodysplastic Syndrome with Monoclonal Anti-Human T Lymphocyte Antibody
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Abstract:
Ten patients with myelodysplastic syndrome (MDS) were treated with monoclonal anti -human T lymphocyte antibodies SMU3 (anti - CD3) and SMU8 (anti - CD8) . The results suggested that two patients got a significant progress and five patients turned better. Before treatment the patients had less CD4 cells, more CD8 cells, lower or inverted ratio of CD4/ CD8, higher expression of HLA -DR antigen than normal control and these differences were significant. After treatment T lymphocyte subsets and HLA - DR expression turned normal. T lymphocyte subsets imbalance and abnormal function in patients is one of the factors which induced MDS.
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