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Effects of IL-3 Gene Therapy on Immune Reconstitution After Bone Marrow Transplantation
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Abstract:
In the present study,the effects of fibroblast-mediated IL-3 gene therapy on immune reconstitution was observed after syngeneic bone marrow transplantation in the mice which had received high-dose chemotherapy. After the treatment,the proliferation of bone marrow cells stimulated by ConA, the cytotoxicity of macrophages, the levels of IL-1, TNF induced from macrophage and IL-2 induced from the splenocyte of experimental mice were augmented significantly. The results suggest that the fibroblast-mediated IL-3 gene therapy could be used to accelerate the process of immune reconstitution and reduce the complication after bone marrow transplantation.
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