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Inhibitory Efficiency on Growth in vivo of B16 Melanoma Cell Expressing Angiostatin
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Abstract:
Objective: Study on the growth character of B16 melanoma cell which can express angiostatin. Methods: Angiostatin gene was constructed from human plasminogen cDNA by deletion mutation. A B16 melanoma cell clone named BAG28 which stably expresses angiostatin was established by introducing gene into it. Results: BAG28 in vitro had no changes in proliferation rate and the ability of clone formation in soft agar. Study in vitro showed that the tumor weight had reduced about 87% ( P < 0. 01 ) 26 days after inoculation in mouse. Conclusion: The growth of B16 melanoma cells expressing angiostain was significandy inhibited in vivo.
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