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Expression of Estrogen and Progesterone Receptors in Bronchogenic Carcinoma
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Abstract:
Objective: To investigate estrogen receptor (ER) and progesterone receptor (PR) in the tumor derived from non-target organ (primary bronchogenic carcinoma), and correlation with the tumor. Methods: According to WHO histo-logical classification of lung tumors, 146 resected specimens of lung canrer were examined microscopically; ER and PR were detected on paraffin-embedded tissue sections using immunohistochemical staining. Results: 58.9% of the cases were positive for ER, 69. 1 % for PR,and 46.6% positive for both. There was a significant correlation between ER and PR positive percentage and degrees of histological differentiation in lung cancer, while ER and PR percentage appears to have no relationship with histological type, tumor size, age and sex of the patients. Conclusion: It is demonstrated that ER and PR are present in non-small cell lung cancer. These observation may provide a basis for adjuvant hormonal therapy in selected lung cancer patients.
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