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The Therapeutic Effect of CEA Recombinant Vaccinia Virus on CEA Positive Tumor
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Abstract:
Objective: To study the therapeutic effect of CEA recombinant vaccinia virus on CEA positive tumor. Methords: The CEA positive cell model of murine Hepa liver cancer was constructed. Then, 40 mice, which were divided into four groups, were injected subcutaneously with CEA positive or CEA negative Hepa tumor cells respectively, and followed by subcutaneous vaccination of wild-type vaccinia virus (W-VV ) or CEA-rV for three times at 14-day interval . The animals responses were observed and the subcutaneous tumors were measured weekly after tumor cells injection. Results: Subcutaneous tumors were observed in all mice. Three control groups tumors grew relatively fast, no statistic significance between these groups were obtained ( P > 0.05), whereas the tumors in group four, which were injected with Hepa-CEA~( ) tumor cells and CEA-rV , grew slowly and the tumor mass was smaller. Comparison with the three control groups, the difference was significant in statistics ( P < 0.01). During the whole testing period, no toxic or side-effects were seen in all animals. Conclusion: The results showed that CEA-rV had well therapeutic effect on CEA positive tumors through inducing the body's immune system to produce CEA specific immune responses.
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