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The Regulation of Expression of Mitochondrion Gene by All Trans Retinoic Acid
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Abstract:
To explore the mechanism of prevention and therapy by retinoic acid in cancer and isolate ATRA-target gene and explore the mechanism of expression regulation of mitochondrial gene. Methods： AP-PCR, hybridization, sequencing etc., were used. Results ： ATRA up-regulated the expression of mitochondrion gene ATPase subunit 6, the change lasted in whole period of ATRA treatment (from first day to seventh day). The up-regulation was confirmed by Northen blot analysis. Two possible retinoic acid responsive elements (RAREs) were located in the regulation region of mitochondrion genome. Conclusion： The mitochondrion gene expression by ATRA might be regulated through the interaction of retinoic acid receptor (RAR) with RARE in mitochondrion genome
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Clc Number:
R730.3
