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The Effect of Whole Peptidoglycan of Bifidobacterium on Cytokines and Cytotoxity Activity Derived from Peritoneal Macrophages of Nude Mice
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Abstract:
To explore the adjustment of whole peptidoglycans of bifidobacteria to macrophage functions. Methods： The level of interleukin 1， tumor necrosis factor α and nitric oxide (NO) produced by peritoneal macrophages of nude mice was detected by employing mouse thymocyte proliferation method killing L929 cell method in vitro and Griess reagent,after whole peptidoglycans were injected into the nude mice peritoneally. Simultaneously, tumoricidal activity of themacrophages in vitro was observed. Results： The content of interleukin 1， tumor necrosis factor α and nitric oxide (NO) secreted from peritoneal macrophages of nude mice was significantly higher in the whole peptidoglycan group when compared with the control group. Futhermore, the tumoricidal activity of the macrophages in vitro was markedly promoted (P<0.01). Conclusion： Whole peptidoglycans of bifidobacteria bifidum could activated macrophages to secrete a lot of cytotoxicity effectors,and elevate its tumoricidal activity.
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Clc Number:
R739.41
