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The Expression of TGF-β1 and Its Type Ⅱ Receptor in Hepatocellular Carcinoma
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Abstract:
To study the role of TGF-β1 and its type Ⅱ receptor in pathogenesis of hepatocellular carcinoma. Methods: The TGF-β1 and its type Ⅱ receptor in the tumor and surrounding tissue in 30 cases with hepatocellular carcinoma were investigated. Results: Levels of protein and mRNA were detected by immuno-histochemistry, hybridization and semi-quantitative analysis. The results showed that TGF-β1 in the tumor and surrounding tissue was overexpressed, and the levels of latter was even higher. TGF-β1 type Ⅱ receptor expressed in surrounding tissue, but it could not be found in most tumor tissues. Conclusion: The lack of TGF-β receptor in the tumor cell may be the way of cancer cells escaping the TGF-β1 action of inhibited proliferation.
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Clc Number:
R730.51
