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Apoptosis of Human Bladder Cancer BIU-87/ADM Cells Induced by Anti-APO-1 Antibody
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Abstract:
To explore the methods of inducing apoptosis in human bladder cancer multidrug resistance cells. Methods： Expression of Fas antigen was detected with immunocytochemistry on BIU-87/ADM cells, and the effect of anti-APO-1 antibody was examined with in situ DNA terminal deoxynucleotydyl transferase assay (TDT)，phase-contrast and electron microscope techniques. Results： We found that Fas antigen was highly expressed on BIU-87/ADM cell surface, and after treatment with anti-APO-1 antibody, survival rate of BIU-87/ADM cells was decreased, apoptotic morphological changes and TDT positive cells were found. Conclusion： These results suggested that anti-APO-1 antibody could induce apoptosis of BIU-87/ADM cells by combining Fas antigen.
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Clc Number:
R730.51
