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Multiple Low-Dose RIT with ~(131)I-C50 in Controlling and Preventing Metastasis in Tumor-Bearing Mice
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Abstract:
Objective: To study the efficiency of radio-immuno-therapy (RIT) with 131I-C50 to precaution and treatment of tumor metastasis and develop a new metastasis suppression method.Methods: The effect was judged through body weight loss, tumor burden, life-span, and metastat- ic. Compared among the multiple low-dose RIT, chemotherapy, surgical resection and controls in different administration time after implantation of tumor and resection of tumor. Results: When the treatment was initiated at 7th day after implantation, the tumor suppression effects of treatment groups were significantly better than those of controls, with the best one in multiple low-dose RIT. Better results were achieved by starting treat- ment earlier. Surgical resection at 15th day after implantation, multiple low-dose RIT groups gained longer life-span and less metastatic nodules than others. Early operation improved therapeutic efficacy, especially in multiple low-dose RIT. Conclusion: Multiple low-dose RIT alone is bet- ter than chemotherapy and surgical treating. Early doing RIT is better than ther. One low-dose RIT Plus with operation had even better tumor suppression effect that RIT alone. Low-dose RIT co-operated with operation as early as possible can enhance the effects of treatment.
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Clc Number:
R73－37 R73－36
