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in vivo and in vitro Anti-tumor Effeciency of B16 Melanoma HSP-Antigen Peptide Complex (HAC)
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Abstract:
To investigate the anti-tumor efficiency of B16 melanoma HACs in vivo and in vitro. Methods: Tris-HCl extract and Sephacryl S-200 gel filtration were applied to prepare B16 HACs, and the cytoloxicity of specific CTL induced by HACs was tested. Results: The 41, 47 and 53 tube HACs obtained by gel filtration could decrease the tumor incidences, delay the time of tumor development and decrease the mortalitites of mice. Conclusion: 60～97 kD HACs from B16 melanoma cytosol have the activites of inhibiting tumor and could be used in effective anti-tumor therapy.
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