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A Randomized and Controlled Study of rhGM-CSF on Leucopenia Induced by Chemotherapy on Cancer Patients
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Abstract:
To evaluate the efficacy and tolerability of rhGMCSF in prevention of neutropenia caused by chemotherapy of cancer patients. Methods: A muticenter, randomized, match and crossover clinical study was conducted. 64 enrolled patients were randomized into AB and BA groups and each patient received two cycles of combination chemotherapy. Zesults: 59 patients were evaluted for clinical efficacy. rhGM-CSF significantly increased the number of WBC and ANC at the stage of nadir. The period when the patients, rhGM-CSF also resulted in a hastening recovery from leucopenia and neutropenia. Conclusion: The administration of rhGM-CSF ensures the implement of sheduled combination chemotherapy. The main side effects such as fever, osteomyalgia, skin rash were generally tolerable.
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